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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3055 | Liensinine Perchlorate | Apoptosis , Others | |
Liensinine is the active constituent of plumula nelambinis with anti-hypertension. | |||
T0459 | Sulindac | Arthrocine,MK-231,Clinoril,Sulindac sulfoxide | COX , Autophagy |
Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl... | |||
T9901A-004 | Labetuzumab | IMMU-14,hMN-14,IMMU-100 | |
Labetuzumab is a humanized anti-carcinoembryonic antigen (CEA) monoclonal antibody with anticancer activity that inhibits tumor growth and is used in the study of thyroid and colorectal cancer (CRC). | |||
T77519 | FC-116 | FC116 | Apoptosis , Microtubule Associated |
FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice. FC-116 induces apoptosis in colorectal cancer (CRC) cells and promotes protein degradation. | |||
T72068 | SFI003 | Apoptosis , ROS | |
SFI003 is a novel SRSF3 inhibitor that exerts anticancer activity against colorectal cancer by modulating the SRSF3 / DHCR24 / ROS axis and driving apoptosis in CRC cells through the SRSF3 / DHCR24 / reactive oxygen spec... | |||
T76890 | Petosemtamab | MCLA 158 | EGFR |
Petosemtamab (MCLA 158) is a highly potent monoclonal antibody against EGFR (Kd: 0.22 nM) and LGR5 (Kd: 0.86 nM). Petosemtamab promotes EGFR signaling disruption and receptor breakdown in LGR5+ cancer cells. Petosemtamab... | |||
T9556 | TNIK-IN-3 | Wnt/beta-catenin | |
TNIK-IN-3 is a highly potent and orally active inhibitor of Traf2- and Nck-interacting protein kinase (TNIK). It exhibits a strong selectivity for TNIK with an IC50 value of 0.026 μM. Additionally, TNIK-IN-3 demonstrates... | |||
T21567L | Cyclosomatostatin Acetate | Cyclosomatostatin Acetate (84211-54-1 Free base) | Somatostatin |
Cyclosomatostatin Acetate is an effective antagonist of the somatostatin receptor.Cyclosomatostatin Acetate inhibits SSTR1 signaling and decreases cell proliferation, ALDH+ cell population size, and sphere-formation in c... | |||
T27163 | DHNQ | ||
DHNQ is a novel inhibitor of the PI3K enzyme activity and transcriptional as well as translational expression levels in colorectal cancer (CRC). | |||
T36742 | CDK5 inhibitor 20-223 | CDK5 inhibitor 20-223 | |
CDK5 inhibitor 20-223, a potent inhibitor of CDK2 and CDK5, demonstrates IC50 values of 6.0 nM and 8.8 nM, respectively. It serves as an effective agent against colorectal cancer (CRC)[1]. | |||
T71624 | GB1874 | ||
GB1874 inhibitor of the Wnt pathway that targets the β-cat-TCF4 PPI. GB1874 also affected the proliferation and stemness of Wnt-addicted colorectal cancer (CRC) cells in vitro. Encouragingly, GB1874 inhibited the growth... | |||
T79933 | (−)-N-Hydroxyapiosporamide | NHAP | NF-κB |
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, serves as an NF-κB inhibitor and demonstrates significant antitumor activity both in vitro and in vivo. It has potential applications in colorectal cancer (CRC) research [1... | |||
T73391 | BLM-IN-2 | ||
BLM-IN-2, a Bloom's Syndrome Protein (BLM) inhibitor, exhibits an IC50 of 0.8 μM and shows efficacy in suppressing proliferation, invasion, cell cycle arrest, and apoptosis in colorectal cancer (CRC) cells, making it a p... | |||
T38519 | YB-0158 | Wnt pathway inhibitor 2,YB-0158 | |
YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a r... | |||
T60030 | NCT02 | ||
NCT02, a cyclin K degrader, promotes the ubiquitination and proteasomal degradation of cyclin K (CCNK) and its complex partner CDK12, showing promise for metastatic colorectal cancer (CRC) research[1]. | |||
T75842 | Cyclosomatostatin TFA | ||
Cyclosomatostatin TFA, a potent somatostatin (SST) receptor antagonist, inhibits type 1 somatostatin receptor (SSTR1) signaling, reducing cell proliferation, the size of the ALDH+ cell population, and sphere-formation in... | |||
T36676 | Rineterkib hydrochloride | ||
Rineterkib hydrochloride (compound B) is an orally active RAF and ERK1/2 inhibitor in the treatment of a proliferative disease characterized by activating mutations in the MAPK pathway. The activity is particularly relat... | |||
T82414 | Favezelimab | MK-4280 | |
Favezelimab (MK-4280) is a humanized anti-LAG-3 monoclonal antibody that inhibits the LAG-3/MHC class II interaction and shows potential for use in colorectal cancer (CRC) research, particularly when combined with the PD... | |||
T61896 | HCAIX-IN-12 | ||
hCAIX-IN-12 is an effective hCAIX inhibitor, IC50 for CAIX and CAII is 0.74 and 10.78 μM , respectively. hCAIX-IN-12 inhibits cell proliferation and induces apoptosis. HCAIX-IN-12 can increase the generation of ROS. HCAI... | |||
T61585 | Sulindac sodium | ||
Sulindac (sodium) (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac (sodium) is used to reduce pain, swelling, and joint stiffness from arthritis. Sulindac is also used for the research of arthr... |